We examine natural plant compounds extracted from regional herbs with anecdotal evidence of efficacious use in traditional and folk medicine. Specifically, we are interested in identification of useful anxiolytic agents. Employing measures of depressive- and anxiety-like behavior in animal models, we have identified anxiolytic and sedative effects produced by root extracts from Levantine wild herbs. Currently, we are in the process of characterizing bioactive compounds from root extracts using chromatographic and mass spectrophotometric analysis to isolate potential chemicals or mixtures which may serve as novel anti-anxiety drugs.

5. Anxiolytic natural plant extracts

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